Article

Optimization of transcription factor genetic circuits

2022-07-05

Abstract excerpt

<h4>Summary</h4> Transcription factors (TFs) affect the expression of mRNAs. In essence, the TFs form a large computation network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends recent advances in artificial neural network optimization. In a simple example, computational optimization discovers a four-dimensional TF network...

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Literature Corpus work: 3ad0fe78-4fef-5dec-8ec5-2899c90728a6
DOI: 10.1101/2022.07.05.498863

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