Article

MYT1L deficiency impairs excitatory neuron trajectory during cortical development

2024-03-07

Abstract excerpt

Mutations that reduce the function of MYT1L, a neuron-specific transcription factor, are associated with a syndromic neurodevelopmental disorder. Furthermore, MYT1L is routinely used as a proneural factor in fibroblast-to-neuron transdifferentiation. MYT1L has been hypothesized to play a role in the trajectory of neuronal specification and subtype specific maturation, but this hypothesis has not been directly test...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ffc9006f-5e05-5437-913e-97b72f5e70ae
DOI: 10.1101/2024.03.06.583632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MYT1L deficiency impairs excitatory neuron trajectory during cortical developmentDOI 10.1101/2024.03.06.583632Read

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.Semantic proximity Read

Autism and Intellectual Disability-Associated <i>MYT1L</i> Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and PhysiologySemantic proximity Read

A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturationSemantic proximity Read

Single-cell transcriptomic catalog of mouse cortical developmentSemantic proximity Read

Cell type-specific gene expression dynamics during human brain maturationSemantic proximity Read

Thyroid hormone promotes fetal neurogenesisSemantic proximity Read

<i>RAI1</i> safeguards fidelity and tempo of human neurodevelopmental gene expressionSemantic proximity Read

Thyroid hormone promotes fetal neurogenesisSemantic proximity Read

<i>DLG2</i> knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognitionSemantic proximity Read

MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention.Semantic proximity Read

Molecular diversity and lineage commitment of human interneuron progenitorsSemantic proximity Read

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brainSemantic proximity Read