Article
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.
Neuron - 1 Dec 2021
Chen Jiayang, Lambo Mary E, Ge Xia, Dearborn Joshua T, Liu Yating, McCullough Katherine B, Swift Raylynn G, Tabachnick Dora R, Tian Lucy, Noguchi Kevin, Garbow Joel R, Constantino John N, Gabel Harrison W, Hengen Keith B, Maloney Susan E, Dougherty Joseph D
Abstract excerpt
Human genetics have defined a new neurodevelopmental syndrome caused by loss-of-function mutations in MYT1L, a transcription factor known for enabling fibroblast-to-neuron conversions. However, how MYT1L mutation causes intellectual disability, autism, ADHD, obesity, and brain anomalies is unknown. Here, we developed a Myt1l haploinsufficient mouse model that develops obesity, white-matter thinning, and...
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