RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding.

Abstract excerpt

<h4>Background: </h4> Ceramide metabolism is crucial in the progress of brain metastasis (BM). However, it remains unexplored whether targeting ceramide metabolism may arrest BM. <h4>Methods: </h4>: RNA sequencing was applied to screen different genes in primary and metastatic foci and whole-exome sequencing (WES) to seek crucial abnormal pathway in BM+ and BM-patients. Cellular arrays were applied to analyze the...

Topics

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• Apoptosis
• Autophagy in Disease and Therapy
• Cancer Mechanisms and Therapy
• Carcinoma, Non-Small-Cell Lung
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Histone Deacetylase Inhibitors Research
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

4cdd3838-d9c4-5f0c-9d84-fa07769b790d

DOI

10.21203/rs.3.rs-3105251/v1