Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.

doi:10.1172/JCI79775

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.

The Journal of clinical investigation - 1 Jan 2016

Suzuki Motoshi, Cao Ke, Kato Seiichi, Komizu Yuji, Mizutani Naoki, Tanaka Kouji, Arima Chinatsu, Tai Mei Chee, Yanagisawa Kiyoshi, Togawa Norie, Shiraishi Takahiro, Usami Noriyasu, Taniguchi Tetsuo, Fukui Takayuki, Yokoi Kohei, Wakahara Keiko, Hasegawa Yoshinori, Mizutani Yukiko, Igarashi Yasuyuki, Inokuchi Jin-ichi, Iwaki Soichiro, Fujii Satoshi, Satou Akira, Matsumoto Yoko, Ueoka Ryuichi, Tamiya-Koizumi Keiko, Murate Takashi, Nakamura Mitsuhiro, Kyogashima Mamoru, Takahashi Takashi

Abstract excerpt

Sphingolipids make up a family of molecules associated with an array of biological functions, including cell death and migration. Sphingolipids are often altered in cancer, though how these alterations lead to tumor formation and progression is largely unknown. Here, we analyzed non-small-cell lung cancer (NSCLC) specimens and cell lines and determined that ceramide synthase 6 (CERS6) is markedly overexpressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Line, Tumor

Share to Ceramides

Share to Lung Neoplasms

Share to Membrane Proteins

Share to MicroRNAs

Share to Neoplasm Metastasis

Source

Open in PubMed Open full text

Identifiers

PMID: 26650179
DOI: 10.1172/JCI79775
PMCID: PMC4701566

Genes

CERS6
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.PMID 26650179Read ↗

Ceramide Synthase 1 Inhibits Brain Metastasis of Non-Small Cell Lung Cancer by Interacting with USP14 and Downregulating the PI3K/AKT/mTOR Signaling PathwaySemantic proximity Read ↗

Implication of Ceramide Kinase/C1P in Cancer Development and ProgressionSemantic proximity Read ↗

The ceramide synthase (CERS/LASS) family: Functions involved in cancer progressionSemantic proximity Read ↗

RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding.Semantic proximity Read ↗

Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.Semantic proximity Read ↗

Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complexSemantic proximity Read ↗

Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancerSemantic proximity Read ↗

Acid Ceramidase: A Novel Therapeutic Target in CancerSemantic proximity Read ↗

Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancerSemantic proximity Read ↗

SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma.Semantic proximity Read ↗

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor GrowthSemantic proximity Read ↗

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.