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Defibrotide inhibits donor leucocyte‐endothelial interactions and protects against acute graft‐versus‐host disease

10 Jun 2020

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is an effective therapy for the treatment of high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. Acute graft-versus-host disease (aGvHD) remains the most frequent cause of non-relapse mortality following allo-HCT and limits its extensive clinical application. Current pharmacologic agents used for...

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PMID: 32519822
DOI: 10.1111/jcmm.15434

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