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Article

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

4 Nov 2019

Abstract excerpt

Allogeneic stem cell transplantation is a cornerstone of curative therapy for high-risk and/or advanced hematological malignancies but remains limited by graft-versus-host disease (GVHD). GVHD is initiated by the interaction between recipient antigen-presenting cells (APCs) and donor T cells, culminating in T-cell differentiation along pathogenic type-1 and type-17 paradigms at the expense of tolerogenic...

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Identifiers

PMID: 31697827
DOI: 10.1182/blood.2019000823

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