Article

Advancing our understanding of genetic risk factors and potential personalized strategies in pelvic organ prolapse: largest GWAS to date reveals 19 novel associated loci

2021-07-10

Abstract excerpt

<h4>Objectives</h4> To identify the genetic determinants of pelvic organ prolapse (POP) and assess the predictive ability of polygenic risk scores (PRS) alone or in combination with clinical risk factors. <h4>Design</h4> Meta-analysis of genome-wide association studies (GWAS) and PRS construction and validation. <h4>Setting</h4> GWAS summary statistics from three European datasets and individual-level data from Es...

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Literature Corpus work: 4ccf4f84-5f18-5f4a-a55e-7a9dad683ce3
DOI: 10.1101/2021.07.08.21260068

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