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Article

Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.

PloS one - 1 Jan 2015

Giri Ayush, Wu Jennifer M, Ward Renee M, Hartmann Katherine E, Park Amy J, North Kari E, Graff Mariaelisa, Wallace Robert B, Bareh Gihan, Qi Lihong, O'Sullivan Mary J, Reiner Alexander P, Edwards Todd L, Velez Edwards Digna R

Abstract excerpt

Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women's Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1-3) or moderate/severe POP (grades 2-3), while controls had grade 0 POP. We performed race-specific...

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Source

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Identifiers

PMID: 26545240
DOI: 10.1371/journal.pone.0141647
PMCID: PMC4636147

Genes

CPE
DPP6
HP
SHC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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