Article
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.
Communications biology - 17 Mar 2020
Olafsdottir Thorhildur, Thorleifsson Gudmar, Sulem Patrick, Stefansson Olafur A, Medek Helga, Olafsson Karl, Ingthorsson Orri, Gudmundsson Valur, Jonsdottir Ingileif, Halldorsson Gisli H, Kristjansson Ragnar P, Frigge Michael L, Stefansdottir Lilja, Sigurdsson Jon K, Oddsson Asmundur, Sigurdsson Asgeir, Eggertsson Hannes P, Melsted Pall, Halldorsson Bjarni V, Lund Sigrun H, Styrkarsdottir Unnur, Steinthorsdottir Valgerdur, Gudmundsson Julius, Holm Hilma, Tragante Vinicius, Asselbergs Folkert W, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Jonsdottir Kristin, Rafnar Thorunn, Stefansson Kari
Abstract excerpt
Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (P < 5 × 10-8);...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.