von Willebrand factor: at the crossroads of bleeding and thrombosis.

doi:10.1007/s12185-012-1041-x

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Article

von Willebrand factor: at the crossroads of bleeding and thrombosis.

International journal of hematology - 1 Apr 2012

Denis Cécile V, Lenting Peter J

Abstract excerpt

Hemostasis and thrombosis represent two sides of the same coin. Hemostasis maintains blood fluidity in the vascular system while allowing for rapid thrombus formation to prevent excessive hemorrhage after blood vessel injury. Thrombosis is a pathologic extension of the normal hemostatic mechanism, occurring when unwanted clot formation develops in certain pathological situations. The molecular mechanisms...

Topics

Animals
Hemorrhage
Humans
Mutation
Protein Conformation
Protein Multimerization
Thrombosis
von Willebrand Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 22477538
DOI: 10.1007/s12185-012-1041-x
PMCID: PMC3677142

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