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Pan-cancer characterization of metabolism-related biomarkers identifies potential therapeutic targets

24 May 2021

Abstract excerpt

BACKGROUND: Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical metabolic pathways, glycolysis and oxidative phosphorylation (OXPHOS), remains poorly defined. METHODS: We developed a "double-score" system to quantify glycolysis and OXPHOS in 9668 patients...

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PMID: 34030708
DOI: 10.1186/s12967-021-02889-0

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