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Metabolic reprogramming shapes the immune microenvironment in pancreatic adenocarcinoma: prognostic implications and therapeutic targets

21 Mar 2025

Abstract excerpt

Introduction Pancreatic adenocarcinoma (PAAD) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapy. Emerging evidence suggests that tumor-specific metabolic reprogramming may drive disease progression and shape the immune landscape in PAAD. Methods We integrated multi-omics data from TCGA, GEO, and ICGC to identify key metabolism-related genes...

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PMID: 40191200
DOI: 10.3389/fimmu.2025.1555287

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