Article

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory Macrophages

2026-05-21

Abstract excerpt

Post-traumatic osteoarthritis (PTOA) is a common long-term consequence of joint injury and a major cause of chronic pain and disability, yet no disease-modifying therapies are currently available. A central barrier to effective intervention is the persistence of maladaptive synovial inflammation, driven in part by macrophage-mediated signaling that sustains tissue degeneration and pain. Here, we developed a scalab...

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Literature Corpus work: 1fdd2d27-fdfa-5119-ac52-22993c19c08e
DOI: 10.64898/2026.05.18.726078

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