Article

Recent advances in understanding the regulation of metalloproteinases

2019-02-18

Abstract excerpt

Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage collagen. Although direct inhibition of MMPs fell out of vogue with the initial clinical disappointment of the first generation of compounds, interest in other mechanism...

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Literature Corpus work: bc2d831d-20d5-519f-b87e-4e2af55dc2ad
DOI: 10.12688/f1000research.17471.1

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