Article

Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic adenocarcinoma

2025-01-29

Abstract excerpt

<title>Abstract</title> <p>This study aims to evaluate the predictive value and therapeutic significance of lactate-related genes (LRGs) in pancreatic ductal adenocarcinoma (PDAC). By analyzing PDAC data from the TCGA and GEO databases and employing WGCNA and consensus clustering, we identified two lactate subtypes with distinct gene expression profiles and clinical outcomes, and extracted differentially expresse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 915a8168-080c-5dc9-a44a-5081bd8a4560
DOI: 10.21203/rs.3.rs-5899024/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic adenocarcinomaDOI 10.21203/rs.3.rs-5899024/v1Read

Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinomaSemantic proximity Read

Hypoxia- and Lactate Metabolism-Associated Prognostic and Therapeutic Signature in Pancreatic CancerSemantic proximity Read

Establishment and Verification of a Novel Gene Signature Connecting Hypoxia and Lactylation for Predicting Prognosis and Immunotherapy of Pancreatic Ductal Adenocarcinoma Patients by Integrating Multi-Machine Learning and Single-Cell AnalysisSemantic proximity Read

Lactate regulators contribute to tumor microenvironment and predict prognosis in lung adenocarcinomaSemantic proximity Read

Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Lactylation-Associated Prognostic Model and Role of ANLN in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Integrated analysis of lactate-related genes identifies POLRMT as a novel marker promoting the proliferation, migration and energy metabolism of hepatocellular carcinoma via Wnt/β-Catenin signalingSemantic proximity Read

Lactate gene signature based on mitophagy predict the prognosis and immune response in lung adenocarcinomaSemantic proximity Read

Development of a Comprehensive Gene Signature Linking Hypoxia, Glycolysis, Lactylation, and Metabolomic Insights in Gastric Cancer through the Integration of Bulk and Single-Cell RNA-Seq DataSemantic proximity Read

Bioinformatics Identification of Lactate-Associated Genes in Hepatocellular Carcinoma: G6PD’s Role in Immune ModulationSemantic proximity Read

Lactate: A regulator of immune microenvironment and a clinical prognosis indicator in colorectal cancerSemantic proximity Read

Lactate-Related Gene Signatures as Prognostic Predictors and Comprehensive Analysis of Immune Profiles in Nasopharyngeal CarcinomaSemantic proximity Read