Article

TRPS1 modulates chromatin accessibility to regulate estrogen receptor (ER) binding and ER target gene expression in luminal breast cancer cells

2023-07-03

Abstract excerpt

Breast cancer is the most frequently diagnosed cancer in women. The most common subtype is luminal breast cancer, which is typically driven by the estrogen receptor α (ER), a transcription factor (TF) that activates many genes required for proliferation. Multiple effective therapies target this path-way, but individuals often develop resistance. Thus, there is a need to identify additional targets that regulate E...

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Literature Corpus work: 4c84082e-c3f5-5d0b-b12a-1865d2a18288
DOI: 10.1101/2023.07.03.547524

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