Article

AGORA2: Large scale reconstruction of the microbiome highlights wide-spread drug-metabolising capacities

2020-11-10

Abstract excerpt

The human microbiome influences the efficacy and safety of a wide variety of commonly prescribed drugs, yet comprehensive systems-level approaches to interrogate drug-microbiome interactions are lacking. Here, we present a computational resource of human microbial genome-scale reconstructions, deemed AGORA2, which accounts for 7,206 strains, includes microbial drug degradation and biotransformation, and was extens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fac88d22-0c28-5e50-a24f-62a115e5ca57
DOI: 10.1101/2020.11.09.375451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AGORA2: Large scale reconstruction of the microbiome highlights wide-spread drug-metabolising capacitiesDOI 10.1101/2020.11.09.375451Read

Systematic mapping of drug metabolism by the human gut microbiomeSemantic proximity Read

Mapping human microbiome drug metabolism by gut bacteria and their genesSemantic proximity Read

A data-driven approach for predicting the impact of drugs on the human microbiomeSemantic proximity Read

A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sitesSemantic proximity Read

A human gut metagenome-assembled genome catalogue spanning 41 countries supports genome-scale metabolic modelsSemantic proximity Read

A metagenomic strategy for harnessing the chemical repertoire of the human microbiomeSemantic proximity Read

Towards a mechanistic understanding of reciprocal drug–microbiome interactionsSemantic proximity Read

Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between drugs and gut-associated microbesSemantic proximity Read

Impact of commonly used drugs on the composition and metabolic function of the gut microbiotaSemantic proximity Read

Personalized Mapping of Drug Metabolism by the Human Gut MicrobiomeSemantic proximity Read

Systematic Metaproteomics Mapping Reveals Functional and Ecological Landscapes of Ex Vivo Human Gut Microbiota Responses to Therapeutic DrugsSemantic proximity Read

Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota.Semantic proximity Read