Gut bacteria generate prodrugs in situ increasing systemic drug exposure

Abstract excerpt

The human gut microbiome has been increasingly recognized as a metabolic compartment that influences health and therapeutic responses. While recent studies have cataloged diverse sets of drug biotransformation reactions as a result of microbial metabolism 1–3 , the pharmacological relevance of the resulting drug metabolites remains mostly uncharacterized. We investigated whether certain microbial drug metabolites...

Topics

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• Berberine and alkaloids research
• Clostridium difficile and Clostridium perfringens research
• Diet and metabolism studies
• Ginseng Biological Effects and Applications
• Gut microbiota and health
• Metabolomics and Mass Spectrometry Studies
• Pharmacogenetics and Drug Metabolism
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

98bbda5c-9adc-5362-b031-9eacb7d361b4

DOI

10.64898/2025.12.09.692405