Article

Hercules: a profile HMM-based hybrid error correction algorithm for long reads

2017-12-13

Abstract excerpt

<h4>Motivation</h4> Choosing whether to use second or third generation sequencing platforms can lead to trade-offs between accuracy and read length. Several studies require long and accurate reads including de novo assembly, fusion and structural variation detection. In such cases researchers often combine both technologies and the more erroneous long reads are corrected using the short reads. Current approaches...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c5b9ff7-6757-5fa8-b9ac-dca6e1ecff77
DOI: 10.1101/233080

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hercules: a profile HMM-based hybrid error correction algorithm for long readsDOI 10.1101/233080Read

Hidden Markov Models in Bioinformatics: SNV Inference from Next Generation Sequence.Semantic proximity Read

An efficient error correction and accurate assembly tool for noisy long readsSemantic proximity Read

Ratatosk: hybrid error correction of long reads enables accurate variant calling and assembly.Semantic proximity Read

HQAlign: Aligning nanopore reads for SV detection using current-level modelingSemantic proximity Read

High-throughput annotation of full-length long noncoding RNAs with Capture Long-Read SequencingSemantic proximity Read

Jovian enables direct inference of germline haplotypes from short reads via sequence-to-sequence modelingSemantic proximity Read

Vulcan: Improved long-read mapping and structural variant calling via dual-mode alignmentSemantic proximity Read

LRTK: A platform agnostic toolkit for linked-read analysis of both human genomes and metagenomesSemantic proximity Read

Generative Haplotype Prediction Outperforms Statistical Methods for Small Variant Detection in NGS DataSemantic proximity Read

GBScleanR: robust genotyping error correction using a hidden Markov model with error pattern recognition.Semantic proximity Read

Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic librariesSemantic proximity Read

PyroHMMsnp: an SNP caller for Ion Torrent and 454 sequencing data.Semantic proximity Read