Article

Vulcan: Improved long-read mapping and structural variant calling via dual-mode alignment

2021-05-30

Abstract excerpt

<h4>Background</h4> Long-read sequencing has enabled unprecedented surveys of structural variation across the entire human genome. To maximize the potential of long-read sequencing in this context, novel mapping methods have emerged that have primarily focused on either speed or accuracy. Various heuristics and scoring schemas have been implemented in widely used read mappers (minimap2 and NGMLR) to optimize for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fd17467-d413-5f26-ba36-cc911b066458
DOI: 10.1101/2021.05.29.446291

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vulcan: Improved long-read mapping and structural variant calling via dual-mode alignmentDOI 10.1101/2021.05.29.446291Read

Benchmarking long-read aligners and SV callers for structural variation detection in Oxford nanopore sequencing data.Semantic proximity Read

Dysgu: efficient structural variant calling using short or long readsSemantic proximity Read

inGAP-sv: a novel scheme to identify and visualize structural variation from paired end mapping data.Semantic proximity Read

SVkhor: a unified framework for structural variant integration across long-read, short-read, and optical genome mapping dataSemantic proximity Read

Long-Read Sequencing for Structural Variant Detection: A Scoping Review of Tools, Benchmarking Evidence, and Clinical ApplicationsSemantic proximity Read

A long read mapping method for highly repetitive reference sequencesSemantic proximity Read

SVIM: Structural Variant Identification using Mapped Long ReadsSemantic proximity Read

HQAlign: Aligning nanopore reads for SV detection using current-level modelingSemantic proximity Read

Accelerated, Accurate, Hybrid Short and Long Reads Alignment and Variant CallingSemantic proximity Read

NextSV: a meta-caller for structural variants from low-coverage long-read sequencing dataSemantic proximity Read

MapCaller – An integrated and efficient tool for short-read mapping and variant calling using high-throughput sequenced dataSemantic proximity Read

VolcanoSV enables accurate and robust structural variant calling in diploid genomes from single-molecule long read sequencingSemantic proximity Read