Article

Epistasis between SARS-CoV-2 M and N Proteins Balances Particle Assembly and Immune Evasion

2026-06-30

Abstract excerpt

Since its emergence in the human population, SARS-CoV-2 has continuously evolved to evade immune responses and robustly establish global circulation. In this process, the structural viral membrane (M) protein has accumulated amino acid changes whose impact on viral particle assembly and innate immune evasion remains incompletely understood. Here, we designed a SARS-CoV-2 replicon system lacking M that assesses the...

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Literature Corpus work: 4ad72d80-768f-575e-bd71-0635f6385919
DOI: 10.64898/2026.06.29.735107

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