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Article

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

29 Jul 2025

Abstract excerpt

How SARS-CoV-2 Omicron evolved remains obscure. T492I, an Omicron-specific mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters nonstructural protein cleavage, inferring potentials to drive evolution. Through evolve-and-resequence experiments of SARS-CoV-2 wild-type (hCoV-19/USA/WA-CDC-02982585-001/2020, A) and Delta strains (B.1.617) with or without T492I, this...

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PMID: 40730568
DOI: 10.1038/s41467-025-62300-0

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