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The NSP4 T492I mutation increases SARS-CoV-2 infectivity by altering non-structural protein cleavage.

Cell host & microbe - 12 Jul 2023

Lin Xiaoyuan, Sha Zhou, Trimpert Jakob, Kunec Dusan, Jiang Chen, Xiong Yan, Xu Binbin, Zhu Zhenglin, Xue Weiwei, Wu Haibo

Abstract excerpt

The historically dominant SARS-CoV-2 Delta variant and the currently dominant Omicron variants carry a T492I substitution within the non-structural protein 4 (NSP4). Based on in silico analyses, we hypothesized that the T492I mutation increases viral transmissibility and adaptability, which we confirmed with competition experiments in hamster and human airway tissue culture models. Furthermore, we showed that the...

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Identifiers

PMID: 37402373
DOI: 10.1016/j.chom.2023.06.002

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