Article
Gene from a psoriasis susceptibility locus primes the skin for inflammation.
Science translational medicine - 8 Dec 2010
Wolf Ronald, Mascia Francesca, Dharamsi Alif, Howard O M Zack, Cataisson Christophe, Bliskovski Val, Winston Jason, Feigenbaum Lionel, Lichti Ulrike, Ruzicka Thomas, Chavakis Triantafyllos, Yuspa Stuart H
Abstract excerpt
Psoriasis is a common complex genetic disease characterized by hyperplasia and inflammation in the skin; however, the relative contributions of epidermal cells and the immune system to disease pathogenesis remain unclear. Linkage studies have defined a psoriasis susceptibility locus (PSORS4) on 1q21, the epidermal differentiation complex, which includes genes for small S100 calcium-binding proteins. These...
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