Article
Targetting of desmoglein 1 in inherited and acquired skin diseases.
Clinical and experimental dermatology - 1 Jul 2003
Whittock N V, Bower C
Abstract excerpt
Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. The desmoglein 1 gene (DSG1) is centromeric to the desmoglein gene cluster and spans approximately 45 kb of 18q12, comprising 15 exons. The transcript encodes a precursor protein of 1049 amino acids that is cleaved to yield a mature protein of 1000 residues. This mature protein is expressed in certain...
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