Article

Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal Cells

2026-03-01

Abstract excerpt

Sleep deprivation induces extensive transcriptional remodeling in the brain, yet it remains unclear how much of this response arises directly from sustained neuronal excitation versus systemic and behavioral confounds. Here we establish a reductionist human neuronal cell model to isolate the cell-autonomous consequences of prolonged depolarization. Controlled optogenetic stimulation of human SH-SY5Y neuronal cells...

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Literature Corpus work: 4c4320fb-05b1-5687-b249-180f8ae6aef9
DOI: 10.64898/2026.02.27.708551

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