Article

Functional Human Retinohypothalamic Tract Assembloid Model for Circadian Rhythm Research

2026-01-23

Abstract excerpt

The retinohypothalamic tract (RHT) is the primary pathway for circadian photoentrainment. Rodent models exhibit a significant translational gap for human physiology due to their nocturnal nature. To overcome this, we developed a functional human RHT assembloid by fusing human pluripotent stem cell (hPSC) derived retinal and hypothalamus organoids. Characterization revealed mature retinal ‘brush borders’ and the pr...

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Literature Corpus work: f9166bdb-5f11-5cc8-b85d-d3aeacffb3a5
DOI: 10.64898/2026.01.21.700761

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