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Article

Design and Validation of a Custom Next-Generation Sequencing Panel in Pediatric Acute Lymphoblastic Leukemia.

International journal of molecular sciences - 23 Feb 2023

Gil José Vicente, Such Esperanza, Sargas Claudia, Simarro Javier, Miralles Alberto, Pérez Gema, de Juan Inmaculada, Palanca Sarai, Avetisyan Gayane, Santiago Marta, Fuentes Carolina, Fernández José María, Vicente Ana Isabel, Romero Samuel, Llop Marta, Barragán Eva

Abstract excerpt

The molecular landscape of acute lymphoblastic leukemia (ALL) is highly heterogeneous, and genetic lesions are clinically relevant for diagnosis, risk stratification, and treatment guidance. Next-generation sequencing (NGS) has become an essential tool for clinical laboratories, where disease-targeted panels are able to capture the most relevant alterations in a cost-effective and fast way. However, comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36901871
DOI: 10.3390/ijms24054440
PMCID: PMC10002321

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