Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditis

Abstract excerpt

BACKGROUND: Viral myocarditis (VMC) is an inflammatory myocardial condition triggered by viral infections which involves pathogenic-related damage and immune-mediated damage. However, the precise immunopathogenic mechanisms underlying VMC remain elusive. METHODS: We performed single-cell RNA sequencing on mouse hearts during the acute phase of CVB3-induced VMC. After manually annotating cell types, functional...