Article

The FBXW7-SHOC2-Raptor axis controls the cross-talks between RAS/ERK and mTORC1 signaling pathways

2018-04-06

Abstract excerpt

FBXW7 is a tumor suppressive E3 ubiquitin ligase, whereas the RAS/ERK and mTORC1 are two major oncogenic pathways. Whether and how FBXW7 regulates these two oncogenic pathways are unknown. While SHOC2 is a scaffold protein that activates RAS/ERK signal, whether and how SHOC2 regulates mTORC1 is unknown. Here we showed that SHOC2 is a novel substrate of FBXW7. Upon phosphorylation on Thr507 by ATR, SHOC2 is recogni...

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Literature Corpus work: 4c1adc7c-7a19-5dc9-9f3c-4592257fc242
DOI: 10.1101/296368

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