Article
The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.
Cancer reports (Hoboken, N.J.) - 1 Aug 2021
Kar Rohan, Jha Saurabh Kumar, Ojha Shreesh, Sharma Ankur, Dholpuria Sunny, Raju Venkata Sita Rama, Prasher Parteek, Chellappan Dinesh Kumar, Gupta Gaurav, Kumar Singh Sachin, Paudel Keshav Raj, Hansbro Philip M, Kumar Singh Sandeep, Ruokolainen Janne, Kesari Kavindra Kumar, Dua Kamal, Jha Niraj Kumar
Abstract excerpt
BACKGROUND: Ubiquitin ligases or E3 ligases are well programmed to regulate molecular interactions that operate at a post-translational level. Skp, Cullin, F-box containing complex (or SCF complex) is a multidomain E3 ligase known to mediate the degradation of a wide range of proteins through the proteasomal pathway. The three-dimensional domain architecture of SCF family proteins suggests that it operates...
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