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Article

FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies

19 Apr 2022

Abstract excerpt

FBXW7, a member of the F-box protein family within the ubiquitin-proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases...

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PMID: 35515121
DOI: 10.3389/fonc.2022.880077

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