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Recent Insight on Regulations of FBXW7 and Its Role in Immunotherapy

24 Jun 2022

Abstract excerpt

SCFFBXW7 E3 ubiquitin ligase complex is a crucial enzyme of the ubiquitin proteasome system that participates in variant activities of cell process, and its component FBXW7 (F-box and WD repeat domain–containing 7) is responsible for recognizing and binding to substrates. The expression of FBXW7 is controlled by multiple pathways at different levels. FBXW7 facilitates the maturity and function maintenance of...

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PMID: 35814468
DOI: 10.3389/fonc.2022.925041

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