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Article

RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma.

International journal of biological sciences - 1 Jan 2022

Yue Yangyang, Wu Kaijie, Qian Weikun, Zhu Zeen, Zhang Simei, Zhang Wunai, Zhang Weifan, Wu Shuai, Li Li, Wu Zheng, Ma Qingyong, Xie Keping, Wang Zheng

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high incidence of metastasis and dismal prognosis. As a member of Gas-Gap gene, RASAL2 is involved in the hydrolysis of RAS-GTP to RAS-GDP and abnormal expression in human cancers. Here we firstly described the function of RASAL2 on PDAC to enrich the knowledge of RAS family.We interestingly observed that RASAL2 expression was upregulated in PDAC at...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Identifiers

PMID: 35844783
DOI: 10.7150/ijbs.72204
PMCID: PMC9274491

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