Article

Inferring polygenic negative selection underlying an individual trait as a distribution of fitness effects (DFEs) from GWAS summary statistics

2024-08-02

Abstract excerpt

There has been rising interest in exploiting data from genome-wide association studies (GWAS) to detect a genetic signature of natural selection acting on a given phenotype. However, current approaches are unable to directly estimate the distribution of fitness effects (DFE), an established property in population genetics that can elucidate genomic architecture pertaining to a particular focal trait. To this end,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c0c17d3-90a5-561f-8d52-25d1931c1a0a
DOI: 10.1101/2024.07.29.601707

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inferring polygenic negative selection underlying an individual trait as a distribution of fitness effects (DFEs) from GWAS summary statisticsDOI 10.1101/2024.07.29.601707Read

Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies.Semantic proximity Read

A simple test identifies selection on complex traits in breeding and experimentally-evolved populationsSemantic proximity Read

A Simple Test Identifies Selection on Complex Traits.Semantic proximity Read

Disentangling selection on genetically correlated polygenic traits using whole-genome genealogiesSemantic proximity Read

Widespread signatures of negative selection in the genetic architecture of human complex traitsSemantic proximity Read

Characterizing selection on complex traits through conditional frequency spectra.Semantic proximity Read

Conditional frequency spectra as a tool for studying selection on complex traits in biobanksSemantic proximity Read

Ghat: An R package for identifying adaptive polygenic traitsSemantic proximity Read

Approximation to the distribution of fitness effects across functional categories in human segregating polymorphismsSemantic proximity Read

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traitsSemantic proximity Read

Ghat: an R package for identifying adaptive polygenic traits.Semantic proximity Read

Principled measures and estimates of trait polygenicitySemantic proximity Read