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Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUS <sup>P525L</sup> spinal motor neurons

2024-11-21

Abstract excerpt

Mutations in the gene FUSED IN SARCOMA ( FUS ) are among the most frequently occurring genetic forms of amyotrophic lateral sclerosis (ALS). Early pathogenesis of FUS -ALS involves impaired DNA damage response and axonal degeneration. However, it is still poorly understood how these gene mutations lead to selective spinal motor neuron (MN) degeneration and how nuclear and axonal phenotypes are linked. To specif...

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Literature Corpus work
4bfe1567-953e-5cc4-8354-9e36d056ba4b
DOI
10.1101/2024.11.20.624439
Open publication

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