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Article

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD

8 Aug 2013

Abstract excerpt

FUS is genetically and pathologically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To clarify the RNA metabolism cascade regulated by FUS in ALS/FTLD, we compared the FUS-regulated transcriptome profiles in different lineages of primary cells from the central nervous system. The profiles of FUS-mediated gene expression and alternative splicing in motor neurons were...

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PMID: 23925123
DOI: 10.1038/srep02388

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