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Article

A Genetic Polymorphism in the Pannexin1 Gene Predisposes for The Development of Endothelial Dysfunction with Increasing BMI.

Biomolecules - 31 Jan 2020

Molica Filippo, Quercioli Alessandra, Montecucco Fabrizio, Schindler Thomas H, Kwak Brenda R, Morel Sandrine

Abstract excerpt

Endothelial dysfunction worsens when body mass index (BMI) increases. Pannexin1 (Panx1) ATP release channels regulate endothelial function and lipid homeostasis in mice. We investigated whether the Panx1-400A>C single nucleotide polymorphism (SNP), encoding for a gain-of-function channel, associates with endothelial dysfunction in non-obese and obese individuals. Myocardial blood flow (MBF) was measured by...

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PMID: 32023876
DOI: 10.3390/biom10020208
PMCID: PMC7072696

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