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Rapamycin Differentially Impacts Germline Stem Cell Quiescence Across Diverse Genetic Backgrounds of <i>Drosophila Melanogaster</i>

2025-12-04

Abstract excerpt

In response to ionizing radiation, stem cells enter a state of temporary quiescence, safeguarding the stem cell pool for tissue regeneration. Quiescence requires the inhibition of mTORC1, a kinase complex that promotes growth and suppresses autophagy, and cell cycle re-entry requires the reactivation of mTORC1. The pharmacological inhibition of mTORC1 in quiescent stem cells by rapamycin prevents cell cycle re-ent...

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Identifiers and source

Literature Corpus work
4bc11d55-c5ed-52e8-b3b6-ad675f880713
DOI
10.64898/2025.12.03.689791
Open publication

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