Article
Natural Genetic Variation Impacts Stress-Induced Quiescence and Regeneration in Response to Rapamycin.
Cells - 26 Jan 2026
Peddibhotla Sahiti, Gonzaga Miriam, Zhang Tricia, Goel Yasha, Sun Jun, Harrison Benjamin R, Promislow Daniel E L, Ruohola-Baker Hannele
Abstract excerpt
In response to ionizing radiation (IR), both adult and cancer stem cells enter reversible cell cycle arrest at the G1/S transition to evade apoptosis and subsequently re-enter the cell cycle to regenerate damaged tissue. Entry into and exit from this arrest, known as "quiescence," is governed by the inhibition of mTORC1. The pharmacological suppression of mTORC1 with rapamycin prevents quiescent stem cells from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.