Article

Lowering CD40L expression in Murine Lupus Results in an Increase in Disease Indicators in Female but not Male B6 mice

2025-02-27

Abstract excerpt

Our lab has previously described a mouse model (CD40LΔ5) that produces only 60% of WT CD40L due to a targeted deletion in an RNA binding site within the CD40L message. The CD40LΔ5 mutation, which destabilizes CD40L mRNA during T cell activation, causes disrupted germinal center (GC) formation leading to reduced levels of memory B cells and switched antibodies. In this study, we used our model of limited CD40L expr...

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Identifiers and source

Literature Corpus work: 5b16dc97-b6ca-50f4-9f46-31e5e65aba99
DOI: 10.1101/2025.02.22.639644

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