Article
Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension.
BMC immunology - 15 Dec 2011
Rabieyousefi Moloud, Soroosh Pejman, Satoh Kimio, Date Fumiko, Ishii Naoto, Yamashita Masahiro, Oka Masahiko, McMurtry Ivan F, Shimokawa Hiroaki, Nose Masato, Sugamura Kazuo, Ono Masao
Abstract excerpt
BACKGROUND: Pulmonary hypertension (PH) refers to a spectrum of diseases with elevated pulmonary artery pressure. Pulmonary arterial hypertension (PAH) is a disease category that clinically presents with severe PH and that is histopathologically characterized by the occlusion of pulmonary arterioles, medial muscular hypertrophy, and/or intimal fibrosis. PAH occurs with a secondary as well as a primary onset....
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