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Article

Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes.

Diabetes - 1 Jun 2014

Caruso Michael, Ma Danjun, Msallaty Zaher, Lewis Monique, Seyoum Berhane, Al-janabi Wissam, Diamond Michael, Abou-Samra Abdul B, Højlund Kurt, Tagett Rebecca, Draghici Sorin, Zhang Xiangmin, Horowitz Jeffrey F, Yi Zhengping

Abstract excerpt

Insulin receptor substrate 1 (IRS1) is a key mediator of insulin signal transduction. Perturbations involving IRS1 complexes may lead to the development of insulin resistance and type 2 diabetes (T2D). Surprisingly little is known about the proteins that interact with IRS1 in humans under health and disease conditions. We used a proteomic approach to assess IRS1 interaction partners in skeletal muscle from lean...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24584551
DOI: 10.2337/db13-1872
PMCID: PMC4030113

Genes

IRS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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