Article

Differentiation of human induced pluripotent or embryonic stem cells decreases the DNA damage response

2016-12-18

Abstract excerpt

Genomic integrity is critical for preservation of stem cell function and is, maintained through a robust DNA damage response (DDR) with systemized DNA DSB repair by either the non-homologous end joining (NHEJ) pathway or the homologous recombination (HR) pathway. To examine DDR during stem cell differentiation, human embryonic (hES) and induced pluripotent stem (IPS) cells were exposed to DNA damaging agents and D...

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Literature Corpus work: 4b556176-a720-509a-ae66-8eae80cd0100
DOI: 10.1101/094938

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