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DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

21 Mar 2017

Abstract excerpt

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair systems are fully functional. In this article, we focused on the detection of DNA double-strand breaks (DSBs) by phosphorylated histone H2AX (known as γH2AX) and p53-binding protein 1 (53BP1) in three...

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PMID: 28327192
DOI: 10.1186/s13287-017-0522-5

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