Article
deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.
PLoS computational biology - 1 May 2011
McPherson Andrew, Hormozdiari Fereydoun, Zayed Abdalnasser, Giuliany Ryan, Ha Gavin, Sun Mark G F, Griffith Malachi, Heravi Moussavi Alireza, Senz Janine, Melnyk Nataliya, Pacheco Marina, Marra Marco A, Hirst Martin, Nielsen Torsten O, Sahinalp S Cenk, Huntsman David, Shah Sohrab P
Abstract excerpt
Gene fusions created by somatic genomic rearrangements are known to play an important role in the onset and development of some cancers, such as lymphomas and sarcomas. RNA-Seq (whole transcriptome shotgun sequencing) is proving to be a useful tool for the discovery of novel gene fusions in cancer transcriptomes. However, algorithmic methods for the discovery of gene fusions using RNA-Seq data remain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.