Article

Cholesterol deficiency directs autophagy-dependent secretion of extracellular vesicles

2025-01-12

Abstract excerpt

<h4>SUMMARY</h4> Extracellular vesicle (EV) secretion is an important, though not fully understood, intercellular communication process. Lipid metabolism has been shown to regulate EV activity, though the impact of specific lipid classes is unclear. Through analysis of small EVs (sEVs), we observe aberrant increases in sEV release within genetic models of cholesterol biosynthesis disorders, where cellular cholest...

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Literature Corpus work: e7ba2eb7-d09b-56b0-90b1-395b8a5383c9
DOI: 10.1101/2025.01.11.632510

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