Article

CEBPB, C19MC, and Defective Autophagy Drive Novel Podosomal Belt to Macropinocytosis Transition, Lipid Accumulation, and HBV A-to-I RNA-editing

2025-10-31

Abstract excerpt

<title>Abstract</title> Obesity and neurodegeneration are clinically associated diseases with defective autophagy. However, the genetic, biological, and metabolic underpinnings connecting these diseases are not well-understood. Here we identified a Mitochondria obesity/neurodegeneration (M on ) gene-signature that is shared between obesity, and neurodegenerative diseases. We demonst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5784994c-3865-5485-bc14-900925c6fa63
DOI: 10.21203/rs.3.rs-6805130/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CEBPB, C19MC, and Defective Autophagy Drive Novel Podosomal Belt to Macropinocytosis Transition, Lipid Accumulation, and HBV A-to-I RNA-editingDOI 10.21203/rs.3.rs-6805130/v1Read

Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesisSemantic proximity Read

The Role of the miR-17-92 Cluster in Autophagy and Atherosclerosis Supports Its Link to Lysosomal Storage DiseasesSemantic proximity Read

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolismSemantic proximity Read

Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism DisordersSemantic proximity Read

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-CellsSemantic proximity Read

Ubc9 deletion in adipocytes causes lipoatrophy in miceSemantic proximity Read

CRISPR screens reveal ZBTB17/MIZ1 as a peroxisome regulatorSemantic proximity Read

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes DevelopmentSemantic proximity Read

Long noncoding RNA H19 – a new player in the pathogenesis of liver diseasesSemantic proximity Read

Defective Lipid Droplet-Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115.Semantic proximity Read

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System.Semantic proximity Read

Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytesSemantic proximity Read