Article

Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells

2025-02-13

Abstract excerpt

<title>Abstract</title> <p>B-cell lymphoma 6 (BCL6) is a transcriptional repressor essential for B lymphocyte differentiation and germinal center formation through its BTB structural domain. Overexpression of BCL6 is strongly implicated in the progression of diffuse large B-cell lymphoma (DLBCL), making it a promising therapeutic target. This study aims to identify a novel small molecule, synthesized via proteoly...

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Literature Corpus work: 4ad82289-ab23-5132-9503-570caa9800c8
DOI: 10.21203/rs.3.rs-6003136/v1

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